Log In
Sign Up
About Us
Polymorphic Biosciences is a privately funded research incubator based in Vancouver, BC that explores novel applications of lipid nanoparticle technology. Our projects range from early-stage exploratory research to applied development for commercial applications.
Position Overview
As a Process Development Scientist, you will be responsible for generating the experimental data that drives our LNP manufacturing platform. This is a bench-heavy, independent role requiring hands-on expertise in lipid nanoparticle formulation and tangential flow filtration. We are a small team building something new, and we need someone who brings both rigour and adaptability to the role.
Key Responsibilities
- Serve as the technical lead for LNP formulation and TFF process development, owning the experimental program from study design through to data analysis and reporting
- Establish and maintain the analytical characterization workflow for LNP quality attributes (particle size, PDI, encapsulation efficiency, yield)
- Build the process knowledge base — defining critical process parameters, operating ranges, and reproducibility boundaries
- Develop documentation and workflows to a standard that supports future scale-up and technology transfer into a cGMP environment
- Communicate findings clearly to both internal stakeholders and external partners through presentations, technical reports, and informal updates
- Contribute to the broader R&D program as priorities evolve
Knowledge and Qualifications
Required
- MSc or PhD in chemical engineering, pharmaceutical sciences, bioengineering, or a related field, with 3+ years of relevant industry experience
- Hands-on experience in LNP formulation and tangential flow filtration
- Advanced technical knowledge in process development and Quality by Design (QbD) principles
- Strong experimental design skills with a systematic approach to process characterization
- Familiarity with cGMP concepts and regulatory considerations in the biotech/pharmaceutical industry
- Excellent written and verbal communication skills, with the ability to present technical findings to diverse audiences
- Strong critical thinking, attention to detail, and the ability to work independently in a developing environment
Preferred
- Direct experience working in or supporting a cGMP manufacturing environment
- Familiarity with RNA-based therapeutics (mRNA, siRNA)
What We Offer
- Salary range: $70k – $100k per annum
- Comprehensive medical and dental coverage after 3 months
- Flexible working hours
- Opportunities for professional growth and development
- Collaborative and innovative research environment
- Contribution to cutting-edge therapeutic development
